Immunohistochemistry Kits and Reagents
Biotium HIF1α(HIF1A-84), CF594 conjugate, 0.1mg/mL
HIF1 (hypoxia-inducible factor 1), a heterodimeric transcription factor complex central to cellular response to hypoxia, consists of two subunits (HIF-1 alpha and HIF-1 beta) which are basic helix-loop-helix proteins of the PAS (Per, ARNT, Sim) family. Expression of HIF-1 alpha protein is regulated by cellular oxygen level alterations as well as in oxygen-independent manner via different cytokines (through the PI3K-AKT-mTOR pathway), growth factors, oncogenic activation, or loss of tumor suppressor function etc. In normoxic cells, HIF-1 alpha is proline hydroxylated leading to a conformational change that promotes its binding to the VLH (von Hippel Lindau) protein E3 ligase complex; ubiquitination and followed by rapid proteasomal degradation. Hypoxia as well as chemical hydroxylase inhibitors (desferrioxamine, cobalt etc.) inhibit HIF-1 alpha degradation and lead to its accumulation in the cells, whereas, contrastingly, HIF-1 beta/ARNT (AhR nuclear translocator) remains stab
Surmodics Inc 650 nm Liquid Stop Solution for TMB Microwell Substrates, 100mL
A liquid stop solution used in end point ELISA applications where a TMB substrate is used as the detection mechanism. Absorbance is read in the blue spectral range (650 nm).
Medchemexpress LLC Discoidin domain receptor 1 (DDR1), rat recombinant protein (HEK293, His-tag) | >95.0% | 500 UG
Recombinant rat discoidin domain receptor 1 (DDR1) expressed in HEK293 cells with a C-terminal His tag. This purified protein is designed for biochemical and cell-based studies of collagen-mediated signaling, matrix remodeling, and protein-protein interactions. Purity is reported as greater than 95% by reducing SDS-PAGE, and multiple size formats are available, including a 500 μg option.
- HEK293-expressed rat DDR1 with C-terminal His tag.
- Purity greater than 95% as determined by reducing SDS-PAGE.
- Available in multiple sizes, including a 500 μg format.
- Suitable for biochemical and cell-based assays.
- Useful for studying collagen-mediated signaling, matrix remodeling, and receptor interactions.
Revvity Health Sciences Inc AlphaLISA SureFire Ultra Multiplex Phospho-DAP12 (Tyr91 & total) Detection Kit, 500 Assay Points
AlphaLISA SureFire Ultra Multiplex Phospho-DAP12 (Tyr91 & total) Detection Kit, 500 Assay Points
Abcam TripleStain IHC Kit: M&R&G on human tissue (DAB, AP/Red & DAB/Ni), 6ML
Abcam's TripleStain IHC Kit (ab183291) is designed to be used with user-supplied goat, mouse and rabbit primary antibodies to detect three distinct antigens on a single human tissue or cell samples.
The product is subject to the following: Abcam Restricted Use Statement
ABclonal Technology AIF1/IBA1 Rabbit pAb
This gene encodes a protein that binds actin and calcium. This gene is induced by cytokines and interferon and may promote macrophage activation and growth of vascular smooth muscle cells and T-lymphocytes. Polymorphisms in this gene may be associated with systemic sclerosis. Alternative splicing results in multiple transcript variants, but the full-length and coding nature of some of these variants is not certain.